If you are a
Clinician in need of further information, including a recovery protocol,
you may call Lloyd Phillips at 336-600-1055, or Email: PPL@Mailbox7.net
Update October 15, 2016: To obtain additional data, we are now opening our phones to parents.
Six Year Analysis of Adverse Reactions to the Gardasil HPV Vaccine
Updated October 15, 2016
by Lloyd W. Phillips
Copyright ©2016 Lloyd W. Phillips
An acute activation of the immune system, such as a traumatic injury, surgical procedure, or a vaccination, may trigger an excessive or uncontrollable immune response in the presence of an elevated active or latent pathogen load. This may ultimately result in the activation and virulence of latent pathogens. Reactivated pathogens observed in over 100 children and adults included, but were not limited to: viruses, enteroviruses, protozoa, and spirochetes, including CDC Positive Borrelia burgdorferi, a.k.a. Lyme Disease.
Immune hyperactivation may result in mass apoptosis of infected cells, which may then result in the liberation of the contents and proteins from these bursting cells, including the pathogens contained in the cytoplasm (center), which may result in a sepsis-like condition. Sepsis may compromise the liver and result in vasculitis. When pathogen-infected cells from specific organs break apart due to adjuvant-driven hyperactivated immune cells, the body may form antibodies to these loose proteins that are now circulating in the blood, resulting in a possible attack on any organ where that protein is found. This helps explain how a vaccine can cause an autoimmune disease. The vaccine adjuvant may also produce inflammatory cytokines which may modulate leukocytes. These leukocytes may become infected by reactivated pathogens, and migrate into joints, causing infection, inflammation, and pain. The vaccinated host may now become contagious, and shed these newly reactivated pathogens, together with attenuated viruses from vaccinations. One of the first easily measurable signs of this vaccine adjuvant-induced sepsis-like condition is liver disruption involving the synthesis of 25[OH]vit-D, Vitamin D. Serum 25(OH)vitD will plummet typically well below 30ng/mm. Vitamin D is necessary for C5B in the Membrane Attack Complex component of the immune system. Liver enzymes remain fairly normal after this temporary sepsis, but vitamin D synthesis typically remains low. This compromises the immune system. If/when lipopolysaccharide leaches through an inflamed and Histamine Intolerant gut, Natural Killer (NK) cells become deactivated, which further compromises the immune system. The release of Stress hormones results in the activation of the ATF3 Gene, which deactivates nearby immune cells. Latent (dormant) pathogens may now reactivate with little inhibition, reproduce, and become virulent. Stress hormones initiate proliferation of additional nerve branches in the cone shaped nerve mass in the brain stem called the Medulla, creating a wider pathway for electrical signals from the hypothalamus deep within the brain. The additional electrical stimulation disrupts the Autonomic Nervous System (ANS). Stress hormones also result in an increased stimulation of the Adrenals through the Adrenal Medulla, resulting in depletion of intracellular Magnesium and Potassium, the result of which may present as enzyme and hormone disruption, mood swings, cognitive impairment, (short-term) memory loss and poor concentration, cardiac rhythm abnormalities and pain, seizures, and much more. Variations in MUNC 13-4 may also affect thiamine uptake, possibly through solute carrier anion transporters, resulting in symptoms of a thiamine deficiency, such as fatigue, body temperature fluctuation, etc. The multiple system failures above contribute to Dysautonomia. Multiple pathogens skew symptoms, making it sometimes difficult to differentiate and diagnose any single pathogen.
Five risk factors have been identified for severe and/or life threatening immune reactions to the HPV vaccine, and all five risk factors are associated with, but not limited to, MUNC 13-4(cit) disruption.
HLA DRB1, DR, DQ, B27
Approximately 95% of the study cohort who reported a severe or life-threatening reaction to the Gardasil HPV vaccine tested positive for, or had symptoms consistent with the HLA DRB1, DR, DQ, B-27, or similar Haplotype. Approximately 80% of the members state that they were physically active and involved in various sports activities such as track, cheerleading, swimming, and other sports. They typically report little or no illness in unvaccinated members until they suffer traumatic injury, or receive a vaccination.
Note: These Haplotypes were present in people who received the Gardasil HPV Vaccine, and did NOT report any severe negative reactions. A high active or latent pathogen load appears to be REQUIRED in the host, in order to initiate this syndrome.
ELHERS-DANLOS SYNDROME, Type 3
Approximately 80% of the above study cohort reported a family history of, or had symptoms consistent with Ehlers-Danlos Type-3 (Hypermobility, a.k.a. "double jointed"). Ehlers-Danlos Syndrome, Type-3 has been diagnosed in about 80% of this study group.
Approximately 70% of the above reported or suspected they had Native American Indian, First Nation, or Aboriginal ancestors. Not all study participants reported this Ancestry connection.
A history of Mononucleosis (Glandular Fever) was found to be an extremely high predictor for a severe or life-threatening vaccine reaction.
Asthma has been potentially identified in 15yr old hockey player Michael Fisher, and 12yr old basketball player Meredith Prohaska, as a risk factor for sudden death.
a) In the month following their daughter's receipt of HPV, TDaP, and FluMist, the father of this Australian family spent almost 2 weeks in a hospital for Swine Flu, and his son was also admitted to the hospital with Whooping Cough. This suggests that vaccinating these children makes them not only shed viruses, but also reactivates the viruses in vaccines, and makes them carriers makes them carriers. In a business model for the pharmaceutical industry, this leads to increased profits from additional medications needed to treat those who are newly infected by vaccinated children. Using the current practice of telling parents that their iatrogenicly-infected child is suffering from "Conversion Disorder", the pharmaceutical companies can keep these infected and contagious children in contact with the general public to spread multiple diseases, and even convince health authorities that lucrative "mandatory vaccination" is s the key to stopping these outbreaks. As long as one unvaccina
b) Low Transferrin, dehydration, and receiving a vaccine close to bedtime may play a role in an adverse vaccine reaction. Transferrin levels are inversely proportional to the retention of aluminum, and the vaccine has an aluminum-based adjuvant.
c) Children and adults with Gardasil vaccine-induced
splenomegaly may be at risk of sudden death from a ruptured spleen
during contact sports, such as football.
An ever increasing number of formerly healthy and active children and adults are reporting severe and/or life-threatening adverse reactions after receiving the genetically modified HPV vaccine.
An unusually high percentage report being involved in sports (cheerleading, football, swim-team, volleyball, track, etc.) prior to receiving the Gardasil HPV vaccine. In at least two cases that were investigated early, sepsis was documented. The vaccine appears to reactivate dormant pathogens by first hyper-stimulating the immune system, which results in aggressive apoptosis (cell death). Infected cells burst and spill their contents, including dormant pathogens that exist in the cytoplasm (center) of the cell. These pathogens have been documented to include, but are not limited to: viruses (including enteroviruses); protozoa; spirochetes (including Lyme disease). Pediatricians generally abandon theses patients, possibly because of poor training, or because of the large amount of time to develop and follow up on individualized recovery protocols for these children, which result in such things as simple digestive problems turning into life-threaten Gastroparesis in these children, or a swollen spleen resulting in death for a high school football player. Many of these doctor-abandon patients develop permanent and life-long conditions, such as six foot former high school track long-distance runner Zach O, whose negligent doctors at Kaiser Permanente let him waste away to 108 pounds, and allowed his 25(OH)vit-D levels to drop to 16ng/ml, resulting in permanent damage to his spine due to fractures. Zach O is now 20 years old and can barely walk with the aid of a walker. John is a 19 yr old male on the East Coast. John received the Gardasil HPV vaccine to prevent cancer and genital warts. At 17, John lost his girlfriend one month after receiving Gardasil when he could no longer achieve an erection or control his bladder. Interstitial Cystitis is increasing among HPV vaccine recipients.
Gardasil Syndrome, a.k.a. Vaccine Syndrome, a.k.a.
Gulf War Syndrome, Lyme Disease and Autism:
Gardasil Syndrome, a.k.a. Vaccine Syndrome, a.k.a. Gulf War Syndrome,a.k.a. Phillip-Offit-Wakefield Syndrome, with similar symptoms found in
Lyme Disease and Autism:
Lightheadedness upon standing (POTS Postural Orthostatic Tachycardia Syndrome);
mood swings, irritability, short temper; Inability to
concentrate/poor memory; Pa Histamine Intolerance;
Reactivation and virulence of enteroviruses and other pathogens, including those
associated with biting insects and pets, such as Bartonella (Cat-Scratch Fever),
and Lyme Disease and Irritable Bowel Syndrome, Gastroparesis, plus Thyroid and Gallbladder
disorders have been observed when left untreated; Curvature of the spine or
Idiopathic Thrombocytopenia Purpura (ITP);
Unskilled doctors may typically tell you it's all in your head (Conversion
Lightheadedness upon standing (POTS Postural Orthostatic Tachycardia Syndrome);
mood swings, irritability, short temper; Inability to
concentrate/poor memory; Pa Histamine Intolerance;
mood swings, irritability, short temper;
Inability to concentrate/poor memory; Pain - stomach, heart, joints; Increased sensitivity to light and loud sounds, smells, foods;
Histamine Intolerance;Eczema, acne, hives, rashes;
Reactivation and virulence of enteroviruses and other pathogens, including those associated with biting insects and pets, such as Bartonella (Cat-Scratch Fever), and Lyme Disease andLyme-related infections and co-infections;
Irritable Bowel Syndrome, Gastroparesis, plus Thyroid and Gallbladder disorders have been observed when left untreated; Curvature of the spine orAnkylosing Spondylitis if HLA-B27 gene mutation is present;
Idiopathic Thrombocytopenia Purpura (ITP);
Unskilled doctors may typically tell you it's all in your head (Conversion Disorder)
1) Serum (blood) levels of Vitamin D [25(OH)VitD] will always be low. 2) Comprehensive Cytokine Panel; look for many LPS Stimulated Cytokines to
be 50% or more below the lowest acceptable counts; 3) LabCorp#: 505026; NAME:
HNK1; COMMON NAME: NK-CD57. Results for this test will typically be FAR BELOW
gate, with many lab results falling
below 30. A count of 63 is generally considered the lowest acceptable
1) Serum (blood) levels of Vitamin D [25(OH)VitD] will always be low. 2) Comprehensive Cytokine Panel; look for many LPS Stimulated Cytokines to be 50% or more below the lowest acceptable counts; 3) LabCorp#: 505026; NAME: HNK1; COMMON NAME: NK-CD57. Results for this test will typically be FAR BELOW gate, with many lab results falling below 30. A count of 63 is generally considered the lowest acceptable limit.
Recombinant vaccines, such as the Gardasil HPV vaccine, require a very potent adjuvant and appear to elicit an unpredictably high immune response in children with an elevated pathogen load (Gaston Ramon: 1926), especially in families who carry the with the HLA-DRB1, HLA-B27, HLA-DR/DQ, HLA-DR15, or similar genetic haplotype. This immune hyper-activation can then result in a sepsis-like condition due to mass apoptosis. This mass cell death can result in pathogens that were trapped deep within cell, being spilled into the blood, where they can infect blood vessels and organs, including the liver. The liver will no longer synthesize sufficient amounts of vitamin D, resulting in a vitamin D deficiency (25(OH)vit D falls below 30ng/ml)). This is how the Gardasil qHPV and Gardasil9 vaccines can reactivate multiple dormant pathogens, which now become virulent, resulting in debilitating Chronic Illness. A 2014 peer reviewed and published abstract confirmed our findings: DOI: 10.1371/journal.pone.0098819. We also found that approximately 80% of these patients or members of their family presented with symptoms consistent with Ehlers-Danlos Syndrome, Type 3 (Hypermobility). We also found that approximately 70% reported having Native American Ancestors. Approximately 40% reported that they or a family member had Mononucleosis in the past. Approximately 30% reported a family member with an autoimmune disease.
Prolonged inflammation initiated by powerful vaccine adjuvants such as Amorphous Aluminum Hydroxyphosphate Sulfate (AAHS), may be life-threatening and/or result in cognitive and motor skill disorders in those individuals with multiple genetic mutations which affect:
1) Removal of Aluminum Adjuvants from the host in a timely manner (such as Low or Mutated transferrin)
2) Pathogen Load (such as HLA-DR15)
3) Glutathione production and utilization (such as GSTM1), and
4) Transsulfuration (such as CBS 699t)
Although other mutations may contribute to the cascade of debilitating events, such as C282Y, which is associated with Hemochromatosis, plus other genes associated with Methylation, the above four genetic conditions formed the core group in this study.
The UNPREDICTABILITY of Aluminum Adjuvant Clearance
from the Human Body
- or -
Why ALL Humans Do Not Suffer Vaccine Injuries and acquire Autism
Noted Geneticist Dr Sin Hang Lee found HPV16-L1 Protein fragments from the Gardasil HPV vaccine tightly bound to their Aluminum substrate (adjuvant) in two different autopsy tissue samples from two different deceased teenage girls. One of the deceased teenagers had received her last Gardasil vaccine injection six months prior to her death. The proprietary HPV16-L1 Protein vaccine fragments were still present in her spleen, causing inflammation and continuing to produce antibodies, which were found nearby. The HPV16-L1 protein fragments were still tightly bound to their aluminum substrates.
Modern Science teaches that aluminum adjuvants separate from vaccine components within 24 hours of injection. Aluminum has an atomic size of 0.051 nm, with an electric charge of +3, and may possibly compete with iron (0.064 nm, +3), magnesium (0.066 nm, +2) or calcium (0.099, +2). About 95% of aluminum binds to transferrin and albumin intravascularly, and is then excreted renally. Transferrin is low when iron is high in the body. Many subjects in our study group tested LOW for transferrin. Some in this group tested positive for Hemochromatosis, with a confirmed positive for an associated C282Y genetic mutation.
We hypothesize that low iron or an iron deficiency or an iron excess may all be an extremely important indication of a possible inability to clear aluminum (adjuvants) from the body of a vaccine recipient, resulting in a possible hyper-activation of the immune system, accompanied by possible failure to properly self-limit inflammation. Simply taking iron supplements before the Gardasil vaccination may result in an inability to properly clear the aluminum vaccine adjuvant because the iron may (partially) saturate transferrin, and not allow it to attract aluminum.
We further hypothesize that numerous genetic polymorphisms or alleles of transferrin such as the common G277S, which results in anemia in a significant number of white women, may be of unsuitable atomic weight or electrical characteristics to efficiently attract and transport various aluminum compounds in all humans (Br J Haematol. 2001 Nov;115(2):329-33). Inefficient liver/kidney removal activity may then play a further role in the retention of aluminum adjuvants. The more vaccines administered, the greater the risk of death from failure of methylation and transsulfuration.
The amount of iron, aluminum, or similar substance taken in that day from antiperspirants, food, or perhaps part of an existing body burden, may act to saturate available transferrin, resulting in inhibited transport and excretion of aluminum, allowing the aluminum from a vaccine to be deposited in tissue, resulting in (possible) symptoms of an iatrogenic autoimmune disease. Additionally, the inflammation resulting from an allergic or other reaction to Gardasil or other concomitant vaccines may be sufficient to induce sequestration of iron and aluminum within cells of the reticuloendothelial system. The spleen is the largest organ in the reticuloendothelial system (a.k.a. mononuclear phagocyte system), and this is the exact place where Dr Sin Hang Lee found mutated HPV16-L1 Protein fragments in autopsy tissue from two deceased teens, long after their HPV vaccinations.
Theobald et al, Agents Actions. 1987 Feb;20(1-2):10-6, identified transferrin (TF) as a blocking factor (BF) for histamine in mast cells, but did not reference histamine that may be released by eosinophils in response to an allergic reaction (such as to components in the Gardasil vaccine). If transferrin is low, the blocking action of histamine is inhibited in a dose-dependant manner (PMID2437773), and this appears to be what we observed, which may partly account for the cascade of debilitating GI events found in these subjects with low transferrin, ranging initially from Histamine Intolerance and ending up with Gastroparesis. We observe high eosinophil levels in many subjects, long after vaccination.
Low transferrin, saturated transferrin, or mutated transferrin appears to play a crucial role in the onset of both aluminum adjuvant retention and the manifestation of other conditions, such as Postural Orthostatic Tachycardia Syndrome (POTS). We hypothesize that transferrin levels, transferrin mutations, and other transferrin anomalies such as molecular weight, play a critical role in regulating histamine release from mast cells in the gut, and thus may be responsible for the severity of such disorders as Irritable Bowel, Celiac, and more.
The inclusion of L-Histidine in the Gardasil HPV vaccine appears to suggest that MERCK Pharmaceuticals is including a pre-cursor to histamine to insure, through decarboxylation, that inflammation and perhaps a localized dilation of blood vessels will ensue upon conversion to histamine. Unfortunately, the inflammation may provide new host cells for an existing or dormant pathogen to invade and multiply.
Based on observation and medical dxs of subjects in this well documented study, we find DIRECT parallels with the Autism Community. While we acknowledge that all cases of Autism are not Iatrogenic, after documenting the numerous cascades of metabolic failures due to vaccine adjuvants, which were the root cause of life-threatening failures in genetically compromised cycles (methylation, transsulfuration, etc.) in these children and adults, we are forced to disclose for fear of culpability in this matter, and possible prosecution for concealing facts, we openly state our hypothesis that vaccine adjuvants, especially Amorphous Aluminum Hydroxyphosphate Sulfate (AAHS) may be extremely dangerous and/or life threaten when administered to children and adults with inhibited or mutated transferrin, albumin, or other disruption which may allow the retention of inflammation-causing vaccine components, which may result in a myriad of disorders, ranging from inflamed glial cells that inhibit the production of myelin for nerves (Multiple Sclerosis), to inhibited cognitive and motor skill inhibition, to death.
It is important to note that while vaccine manufacturers claim that vaccines are safe because they have far less aluminum than the food we eat, ONLY 0.3% of the aluminum contaminants in foods are ever absorbed in the GI Tract, while 100% of the aluminum in a vaccine is put directly into the circulatory system. The body has no known use for aluminum.
Based on our studies with older children and adults, we hypothesize that Infants, especially preemies, with low levels of transferrin or ferritin, are more susceptible to vaccine-induced Autism, because the aluminum vaccine adjuvants do not have sufficient or un-mutated transferrin and / or ferritin to bind to. Additionally, we question why the host actually stored the HPV16-L1 aluminum protein fragments in autopsied spleen tissue the case of the two deceased teenage girls investigated by Geneticist Dr. Sin Hang Lee. Huang et al, 1992 and Cannata et al, 1993, found an inverse relationship between ferritin (iron) and aluminum storage in the human body, and virtually all subjects, except those with Hemochromatosis, had low ferritin. Another observation by CANNATI revealed that the presence, or lack thereof, of iron may influence the absorption and uptake of aluminum by the gut, and we did observe aluminum-containing products such as Tums, and even aluminum based antiperspirants, had a profoundly negative effect on many subjects. We observed that aluminum vaccine compounds are not removed from the body in a timely manner, and are free to translocate and damage sensitive neurological centers in the brain, aided by poorly controlled inflammation, resulting in cognitive and motor-skill disorders. Because of this, the administration of (multiple) vaccines to preemies with low transferrin (and /or compromised albumin) might someday be considered a felony in a court of law.
Syncope / Fainting
We observed that Syncope (fainting), following the Gardasil HPV vaccine, may be the result of an acute allergic reaction. Dr. L.C., received the Gardasil HPV vaccine in 2006 while attending medical school. She returned to class after receiving the HPV vaccine, and lost consciousness. Her vitals were taken, and it was documented that her blood pressure had plummeted to a life-threatening 50/32. We hypothesize this "fainting" was due to an acute allergy-related response to the yeast and/or other component(s) in the vaccine, which resulted in a massive histamine release from eosinophils and mast cells. This elevated histamine would have quickly dilated blood vessels, and would account for the extreme drop in blood pressure. Eosinophils are capable of releasing 80% of their stored histamine in a matter of minutes. We suspect that these children and adults may not have been properly screened for an allergic reaction as warned in the vaccine package insert, especially an allergy to mold and other members of the Fungal Kingdom. Fortunately for Dr. L. C., she did not drive home after her vaccination and die in a car crash. Warnings were not issued by the FDA until three years later (2009).
Physical Activity as a Risk Factor for an Adverse Vaccine Reaction
We observed that children who appeared to be very healthy prior to receiving the Gardasil HPV vaccine and were the most physically active following the vaccination (participated in sports, cheerleading, dancing, biking, skating, or other physical activity), suffered the most sever debilitating symptoms, possibly due to the increased distribution of the vaccine throughout their body due to increased circulation from exercise. We observed that children and adults who appeared to be very healthy may actually have harbored the Human Leukocyte Antigen (HLA) genetic mutation, and the immune system may not have aggressively responded to viruses and other pathogens. This may have given a false sense of good health, and may actually have allowed the host to harbor high(er) levels of Epstein Barr Virus and other pathogens. A family history of EBV or Mononucleosis/Glandular Fever (full blown EBV) has been virtually a 100% predictor of a severe or life-threatening adverse vaccine reaction in this group. People of Irish descent or similar Northern European ancestry (Scotch, English, Swedes, Danes, etc.) have proven to be the most severely affected.
Transferrin and albumin normally bind to and clear the inflammatory vaccine particles and adjuvant within the vasculature in a timely manner, but when they don't, these particles can settle in tissue or bone, and that may be your reason for reading this Abstract - to find out what went wrong, and how to recover your patient.
According to Kahla et al, 2012, (doi: 10.1590/S1517-83822012000200039. Epub 2012 Jun 1), injecting the Gardasil HPV vaccine into these children and adults, along with the HPV virus-contaminated fragments admitted to by the the manufacturer, MERCK & Co., will increase the risk of (cervical) cancer in the vaccine recipient by 500% in the presence of an Epstein Barr Virus infection. Kahla et al found that an EBV infection acts as a co-factor for the induction of cervical cancer by favoring integration of HPV DNA. We observed similar results in a significant number in our study group.
Low Vitamin D
Vitamin D levels appear to plummet (25 Hydroxy Vitamin D) in this group following the administration of the Gardasil HPV vaccination. Several had been tested months prior to the administration of the HPV vaccine, and lab tests for serum Vitamin D were reported to be within gate. Typical 25 Hydroxy Vitamin D post Gardasil averaged around 20, with some dipping to 12.
Low Intracellular Magnesium
Intracellular magnesium quickly becomes depleted following administration of the Gardasil HPV vaccine. However, serum magnesium typically remained on the low side of lab normal.
The Importance of Vitamin E
We observed that many who were tested showed positive for Recent EBV. Chen et al, 2003 Aug;113(2):228-33 suggested the use of Vitamin E to inhibit EBV in cases of Oxidative Stress. Based on the Chen's scientific work, we added Vitamin E to the suggested supplement regimen with positive results.
Magnesium and the "Fight or Flight" Response
Our findings indicate that the immune system may not be capable of distinguishing between fear and the inflammation caused by aluminum adjuvants and other ingredients in modern vaccines. Both fear *and* inflammation were observed to trigger the "Fight of Flight" response, which forced the subject to excrete magnesium.
The human body uses magnesium in the production of about 300 different enzymes. When intracellular (within the cell) magnesium becomes depleted, it is virtually always missed by doctors who look at serum (blood) magnesium. Every cell in the body will contribute its last bit of magnesium to keep the heart pumping. We observed multiple symptoms of a magnesium deficiency: muscle jerks and spasms; pain; irritability; newly acquired panic disorders; heart arrhythmias; headache; and more. One mother described her daughter as the "she bitch from hell" after receiving the Gardasil HPV Vaccine.
Since many cycles fail (methylation, H3K4 Trimethylation, etc.), we observed that it was necessary to administer some vitamins in their active form to maintain proper serum levels. This was especially true of Vitamins B6 and B12.
Symptoms of Vitamin B1 Deficiency (Beriberi): Thiamine Tetrahydrofurfuryl disulfide
Although many of the subjects received Vitamin B1 supplements, we observed many symptoms of a Vitamin B1 (Thiamine) Deficiency. Thiamine is involved in a variety of glucose metabolism-related and neurological functions, including the making of myelin. Many symptoms of the B1 Deficiency decreased when Thiamine tetrahydrofurfuryl disulfide (TTFD) was administered. Allithiamine is one alternative name for TTFD, a fat-soluble form of Vitamin B1.
We acknowledge the observed genetic deficit(s) in the Transsulfuration Cycle due to the CBS gene, and confirm the findings of, DETH R et al, Thomson, and others who documented that oxidative stress plays a critical role in the utilization of Thiamine in the human body.
Genetics and Pathogens
The Human Leukocyte Antigen (HLA) Serotype was present in most who were tested. The HLA-DR15 mutation was found in those most seriously affected. Those with HLA-DR15 appeared acutely sensitive to mold, and exposure would cause a re-emergence of debilitating symptoms.
Genetics and Transsulfuration
Many tested positive for the CBS Gene, and were not able to properly process sulfur. The Cystathionine Beta-Synthase gene, especially the CBS 699t genetic mutation, appeared to be causing a life-threatening cascade of events in these patients, and we observed the following sulfur-related symptoms:
Low Glutathione - Sulfur is required for Glutathione synthesis. ALL who were tested had low glutathione levels.
Connective Tissue Disorders - Sulfur is responsible for Collagen Synthesis, and lack of sulfur leads to poor tissue (skin) structure and strength.
Inflammation - low sulfur can lead to the progression of inflammation and degenerative disorders
Note: Medical Practitioners should be aware that an infant or toddler who screams for prolonged periods, or any child who bangs their head, may actually be signaling that they are experiencing a breakdown in the TRANSSULFURATION Pathway (CBS Gene). When sulfur is not properly metabolized, EXCRUCIATING HEAD PRESSURE may result when sulfites enter the brain and produce acute pain. You should always be on guard that a migraine may be a warning sign of a CBS Gene mutation, especially CBS 699t.
We hypothesize that sulfur-related sustained inflammation, especially involving inflamed glial cells in the brain, may affect nearby Oligodendrocytes, which may then inhibit myelin production, and result in demyelinating disorders, such as Multiple Sclerosis.
Histamine Intolerance and Sustained Inflammation
We observed that the majority of subjects developed a Histamine Intolerance, which we believe contributed to self-sustaining inflammation. This Histamine Intolerance did not appear to be present prior to the administration of the Gardasil HPV vaccine, nor was there a prior indication or family history of Mastocytosis. We took note of the extensive research done by Husheng Li et al., at the University of Tennessee, Knoxville, into how aluminum vaccine adjuvants activate caspase-1 and induce an IL-1beta and an IL-18 release. We hypothesize that the release of IL-1beta and Interleukin-18 (and possibly other pro-inflammatory cytokines), may have inflamed the gut and caused a breakdown of the mucosal lining. This appears to have allowed immune cells in the lining of the gut to come into contact with food proteins as they traveled through the gut. The immune cells appear to have made antibodies to some of these food proteins, and when these foods were again eaten at a later date, the immune system appeared to treat these food proteins as allergens, and trigger mast cells to produce histamine.
Histamine (elevated) and Blood Vessel Dilation
We observed that the majority of these children and adults felt lightheaded upon standing. We hypothesize that the elevated histamine, caused by this newly acquired histamine intolerance, dilated blood vessels, and significantly lowered blood pressure to the brain. We further hypothesize that this may be the cause, or a contributing factor to Postural Orthostatic Tachycardia Syndrome (POTS). We observed that this newly formed histamine intolerance and resulting self-sustaining inflammation did not noticeably subside until foods containing moderate to high amounts of histamine were removed from the diet. We observed that Low Dose Naltrexone appeared to reduce/ eliminate gastrointestinal pain and other negative effects of this condition. Low Dose Naltrexone did not totally eliminate head pain, which we believe is due to an inhibition of the transsulfuration pathway, which allows sulfites to enter the brain.
Sudden Infant Death Syndrome
We further observed that under these conditions, the body appeared to reduce circulation to extremities, leaving the arms and legs of the host feeling cold to the touch, and wanting blankets even on warm days. We further hypothesize that under these conditions, blood volume may be somewhat reduced, and confined mainly to the trunk, especially when lowered salt intake was present. Under these conditions, taking a hot shower may have caused the deaths of several children and adults when extremities were quickly warmed, and blood pressure plummeted due to circulation being restored to these freshly warmed arms and legs, which lowered blood pressure to the heart and brain. Many parents have stated during interview that their child lost consciousness while taking a bath or shower, or shortly thereafter, and we now warn families of the risk of injury from losing consciousness, and the possibility of cardiac arrest.
We hypothesize this (histamine-induced) mechanism that results in sudden lowering of blood pressure in the head and trunk of the body may have already resulted in shock and possibly cardiac arrest in the deaths of several teens. We strongly suggest that medical professionals warn individuals who acquire acute symptoms of POTS or lightheadedness, that they should avoid hot showers and baths.
Astasia-abasia (inability to walk or stand properly)
Astasia-abasia (an inability to stand and/or walk properly) was observed in about 20% of the people in this group at one time or another, typically within days of receiving the HPV vaccine. These children and adults also typically complained about feeling pain in hip joints, which sometimes extend downward through the thigh muscle. About 1 in 20 was confined to a wheelchair for more than one month, while 3 out of a hundred were confined to a wheelchair for at least 6 months.
PCOS and Dysfunctional Uterine Bleeding (DUB) [Heavy and/or Irregular Cycles]
We observed many girls to have heavy and /or irregular cycles. Break-through bleeding was also noted. In one case, a 24 yr old Asian girl who had been ill since she was in her teens, presented with fevers and 10 day cycles. She was subsequently diagnosed with Chronic Active Epstein Barr Virus (CAEBV), and was the only one in the group of over 100 to be diagnosed with EBV in the chronic form. Titers were 10x gate.
A significant number of other young girls were eventually diagnosed with newly acquired PCOS. Many girls were placed on oral birth control in an attempt to regulate periods and flow with generally negative affects. Many of these girls then presented with a raised, bumpy rash, mainly on the trunk of the body, which sometimes extended to the face and ears. This hive-like rash typically appeared within one to three days of ingestion of oral birth control.
Allergies to CITRIC ACID in foods, soft drinks, preservatives, etc.
We observed that new and increased sensitivities to mold and members of the Fungal Kingdom was common. We hypothesize that due to the failure of the host to timely clear the vaccine and its inflammatory payload, the host not only formed antibodies to the HPV Proteins in the vaccine, but also appeared to form aggressive antibodies to fungus (the HPV vaccine proteins are grown in a fungus). We further observed and investigated what turned out to be a related phenomenon. Because of this new or enhanced sensitivity to fungus, many of these children and adults now responded acutely to anything that contained citric acid, including the minute level of citric acid preservative found in a power-bar. After a lengthy investigation, we found that virtually all citric acid sold in the United Stated was manufactured synthetically by means of fermentation, and the favorite fermenting agent was Aspergillus Niger, a cousin to the fungus in the Gardasil HPV vaccine. By putting 10,000 gallons of corn oil or similar sugar-rich base in a vat, then adding Aspergillus Niger (black mold) and waiting a while for it to ferment, you didn't have to use lemons, limes, etc., or have to worry about citrus crop failures, or clean up peels, seeds, or leaves. You just had to filter out the mold at the end of the fermentation process... * BUT * .. you can't filter out the MYCOTOXINS, and this was what was causing many patients to experience a re-emergence of debilitating gastrointestinal and auto-immune symptoms. Whenever they ingested this commercially-made citric acid, many had varying degrees of adverse reactions, some lasting for days.
We observed that a the majority of people with Astasia-abasia also complained of heart pain. They described it as feeling that someone was squeezing their heart. We suspect this may be due to Pericarditis or possibly Pericardial Effusion.
In the remainder of the group whose gait was not severely affected, only about 1 in 10 complained of heart pain. We hypothesize that since the heart muscle and pericardium may have a higher sensitivity to elevated levels of homocysteine (Jhee et al, 2005, doi:10.1089/ars.2005.7.813), the risk of cardiovascular events and /or death may increase due to a further elevation of homocysteine resulting from inhibited transsulfuration.
Head Pressure (acute)
The majority of children and adults who develop debilitating and/or life threatening conditions reported severe head pressure, ranging from minutes to several days after receiving the HPV vaccine. Typical onset was about 1 to 3 hours, accompanied by fatigue. Those who received concomitant vaccines appeared to have a quicker onset of new medical conditions, many after just one HPV vaccination.
We hypothesize that this quick-onset head pressure may be due to histamine or other factors affecting the integrity of the blood brain barrier, especially the Polysorbate-80 Tween contained within the vaccine, together with both the inflammatory properties of the vaccine and its adjuvant, and possibly the inability of the host to process the aluminum (low or mutated transferrin ) and sulfur (sulfate) found in the aluminum adjuvant, which may be aided in part by a genetic mutation negatively affecting Cystathionine Beta-Synthase in the first step of transsulfuration.
Hair Loss - (antibodies to Hair Keratin, Mitochondria, and Heat Shock Protein)
Virtually all girls in this study reported varying degrees of hair loss. The hair loss was traced to the antibodies made by the host in response to the HPV16-L1 protein fragments from the Gardasil HPV vaccine. This was found using the BLAST genetic search engine. Hair loss appeared to peak about 1 - 2 years after the first Gardasil vaccination. In addition to HAIR KERATIN, the antibodies produced against the HPV16-L1 Protein in the Gardasil HPV vaccine also negatively impacted Mitochondria, Heat Shock Protein, and more. Heat Shock Proteins are strongly associated with the cardiovascular system, cancer, and the immune system. Schlesinger et al, 1990, reveals that heat Shock Proteins are also signaled in response to heavy metals. We observed elevated metals in many of these subjects, including but not limited to: nickel, aluminum, and copper (Pyroluria was diagnosed in a small percent).
Of the girls in this study who became pregnant after suffering adverse effects as a result of the Gardasil HPV vaccination, approximately 30% suffered miscariages. We hypothesize that increasingly elevated homocysteine levels and decreases in Interleukin-10 may be responsible for the abortive effects associated with the Gardasil HPV vaccine. Cystathionine Beta-Synthase expression (production) appeared to decrease due to the resulting inflammation caused by the onging (hyper) active immune response, which then resulted in elevated homocysteine. Elevated homocysteine has been associated with terminated pregnancies. The decreased transsulfuration observed in many of these subjects may result in decreased glutathione activity and a further increase in inflammation, plus a suspected decrease in Interleukin-10, an anti-inflammatory cytokine normally elevated during pregnancy. Decreased Interleukin-10 availability in the human body may help sustain inflammation and cause the fetus to be wrongfully recognized as foreign, rather than "self".
After becoming ill as a result of the Gardasil HPV vaccine, we observed that the MAJORITY of these children and adults are negligently diagnosed with "Conversion Disorder" and seen by typically 15 or more doctors and specialists in both private practice or hospital settings. The average person had 10 or more visits to emergency departments, mostly for pain, breathing, or heart-related issues.
We observed this group to be very susceptible to the Placebo Effect, and offer the following explanation: Since one of the key signatures of this syndrome is oxidative stress, we hypothesize that any reduction in stress, including simply thinking or hoping that a pill or treatment will work, may have a relaxing effect upon the patient that may reduce oxidative stress, which may then result in the reduction of adrenaline, cortisol, and the production of pro-inflammatory cytokines. For this reason, the subject's immediate health may appear to improve, even if the treatment may later prove to be harmful.
We observed cortisol to typically be low in the morning, with some of the more seriously affected presenting with symptoms similar to Addison's.
Insomnia was present in the majority of the subjects. We attribute this (in part) to the pineal gland possibly being inhibited by cortisol which was released in response to inflammation, including inflammation associated with the newly acquired histamine intolerance. In addition to mitigating Histamine Intolerance, we observed that Low Dose Naltrexone also helped to relieve insomnia, allowing for approximately five hours of uninterrupted sleep.
Pathogens and Body Burden
The most common enterovirus we observed was Epstein Barr Virus (EBV). EBV was shown act as an incubator for other pathogens and infect fast-growing cytokines when inflammation is present. A previous history of Mononucleosis (Glandular Fever) was virtually a 100% predictor of a life-threatening adverse reaction to the Gardasil HPV vaccine, and similar results were observed among families of autistic children. The antiviral, Famvir, has shown to be safe and effective in a small, but significant number.
Only one out of approximately 100 families observed or interviewed was eventually diagnosed with Chronic Active Epstein Barr (CAEBV), characterized by 10-14 day menses, accompanied by fever.
Vector borne pathogens such as Bartonella, Borrelia Burgdorferi (Lyme Disease), Mycoplasma Pneumoniae, Babesia, and FL1953 (Protomyxzoa Rheumatica), were the most commonly observed pathogens. Several would typically be found together in the children who were tested. Bartonella was never found alone without the presence of other Bunyaviruses.
Note: NK-CD57 counts typically ranged between 8 and 51, with the majority falling at or below 22.
A history of Mononucleosis (Glandular Fever), Mycoplasma/Mycoplasma Pneumoniae, Acne Vulgaris (which can turn Interleukin-10 into Viral Interleukin-10 (vIL10)), and eczema were identified as risk factors for a severe adverse reaction. Interleukin-10 is associated with controlling inflammation.
(a) Livedo Reticularis
Livedo Reticularis is a purplish lace-like "rash" that appeared on the body of a significant number of subjects subjects in this study group. Several were diagnosed with Anti-Phospholipid Syndrome, but none with Sneddon's Syndrome. Because virtually all members of this group were of Western European Ancestry, we acknowledge the possible presence of Mutations in the medium chain acyl-CoA dehydrogenase (MCAD) gene as described by Tanaka et al, (Hum Mutat. 1992;1(4):271-9), which results in an MCAD deficiency.
In addition to the possible presence of the MCAD gene and Anti-Phospholipid Syndrome, we hypothesize that the manifestation of Livedo Reticularis in these children and adults may also be associated with the Lupus-like symptoms we observed, and may also be the result of a combination of elevated histamine combined with the inhibited removal of calcium from the circulatory system (a form of Calciphylaxsis) due to contributing factors which include, but are not limited to: 1) Low Vitamin D; 2) Low Intercellular Magnesium; 3) Low Vitamin K2.
We believe that the dilation of blood vessels and capillaries by histamine contributes to lowered blood flow and blood pressure, which may aid the retention of calcium and other materials in the lining of blood vessels. To prove this hypothesis, we suggested the daily administration of 5,000 iu vitamin D, together with 150 milligrams Magnesium Glycinate twice daily, plus 45 micrograms of Vitamin K2 in the form of Menaquinone, which reportedly also serves as a neuroprotector. Some caregivers later reported that the Livedo Reticularis had improved. We further believe that malabsorption and / or nutrient depletion played a key role.
Hives were common among this group, and may be the result of elevated histamine production and / or a failure of the body to regulate and eliminate histamine.
(c) Molluscum Contagiosum
Molluscum Contagiosum, a contagious but benign viral disease of the skin, has been observed and medically diagnosed in some members of this study group. The raised bumps that appear may also be called "water warts", were typically not painful. They appeared from the face to the genitals, and may be mistaken for genital warts. We question if MERCK Pharmaceuticals is taking advantage of this similarity when promoting their Gardasil HPV vaccine against genital warts. The Gardasil HPV vaccine WILL NOT prevent this type of infection, and we observed the Gardasil HPV vaccine appeared to make the condition worse in these immunocompromised individuals. We further believe that vaccinating a person with Molluscum Contagiosum will result in a severe adverse vaccine reaction to that individual.
(d) Henoch–Schönlein Purpura (HSP)
a.k.a. Schönlein–Henoch Purpura, Anaphylactoid Purpura, and Purpura Rheumatica
A significant number of children and adults reported feeling a tremor sensation in extremities, especially hands and forearms, but neither they nor the people around them could detect any movement.
Eczema, Acne, or other Face Specific Rash
Many of the female children and adults developed an eczema-like rash on their face within weeks of receiving their Gardasil HPV vaccination. These conditions appeared to be a risk factor for an adverse vaccine reaction if present prior to HPV vaccination.
A significant number of female subjects developed Interstitial Cystitis, including many months after they appeared to be feeling better. We suspect, but cannot confirm, that the failure of the transsulfuration cycle may have contributed to this condition.
Need for specialized testing after vaccination
Upon closer examination, it was found that a COMPREHENSIVE CYTOKINE PANEL would have uncovered the underlying inflammation if the attending professional would have observed LPS Stimulated Cytokine counts, which we found to be typically 25% below the lowest acceptable lab levels (lower gate). Additionally, virtually all of the subjects who were tested had NK-CD57 absolute counts falling between 8 and 22, instead of the "lab normal" range of 63 to 360 counts (LabCorp #505026; HNK1 CD57). It is important to note that "Conversion Disorder" in these numerous cases was a costly misdiagnosis for these children and adults, and the loss of time before proper treatment and diagnosis resulted in further failure of methylation cycles and transsulfuration, and only contributed to further nerve damage, such as the demyelination resulting from the inhibition of Oligodendrocytes due to inflammation from surrounding glial cells.
Gardasil HPV may actually Increase Cancer Risk
We observed that the Gardasil vaccine (and possibly others), can disrupt methylation cycles by initiating inflammation that fails to properly self-limit in some individuals. We observed this this long-term inflammation produced symptoms of oxidative stress. Kassner et al, 2013 (Open Biol. 2013 Oct 2;3(10):120173. doi: 10.1098/rsob.120173) demonstrated that disruption of certain areas of methylation can disrupt the production of poly-ADP-ribose formation due to oxidative stress. Poly(ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family and contributes to DNA repair and genomic stability, according to László Virág et al, 2002 (Pharmacological Reviews September 1, 2002 vol. 54 no. 3 375-429). László also confirmed that overexpression, due to oxidative stress, culminated in cell dysfunction or necrosis, and further stated that "This cellular suicide mechanism has been implicated in the pathomechanism of stroke, myocardial ischemia, diabetes, diabetes-associated cardiovascular dysfunction, shock, traumatic central nervous system injury, arthritis, colitis, allergic encephalomyelitis, and various other forms of inflammation."
We hypothesize that inhibition of this and other methylation cycles, such as H3K4 trimethylation, may also contribute to mutations and malignancies by inhibiting the production of Semaphorin 3F and others, which may be responsible for the identification and destruction of corrupted DNA that is beyond repair.
Based on the debilitating flares of sustained inflammation found in these formerly atypical children and adults following administration of the Gardasil HPV Vaccine, we believe that the Gardasil vaccine (and possibly other vaccines) was the proximate cause of the debilitating disorders and associated cancer-related conditions found in a significant number of these children. We also note that the susceptibility for cancer is heightened in the group we observed because of the combination of the inflammation initiated or enhanced by the HPV vaccine, together with the presence of EBV. We also call attention to Epstein–Barr nuclear antigen 1 (EBNA1), which is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV) (Humme et al, 2003). EBNA1 is the only EBV protein found in all EBV-related malignancies. (Duellman, 2009), (Young et al, 2004)
Kahla et al, 2012, observed that the HPV16 virus by itself is not significant enough to cause cervical cancer, but adding EBV to the equation increased the chance by 500%. Many of these children and adults were positive for EBV.
Conclusion: In a significant number of children and adults, the HPV Vaccine may actually be responsible for causing debilitating disorders and malignancies by initiating sustained inflammation. Because the HPV vaccine can reactivate viruses and pathogens, including those associated with encephalitis (especially HHV6) and Lyme Disease (Bartonella, etc.), it is well documented in MERCK's PDR that up to 70% of the related encephalitic conditions (and the possible resulting inflammatory-related malignancies) may occur years later (click for PDR reference). This helps account for vaccine-delayed injuries.
One last finding is a confirmation of the work of Jill James et al (doi: 10.1007/s10803-008-0591-5), who discovered that the parents of autistic children suffered from gene mutations that involved abnormal methylation and transsulfuration. We found similarities in parents and children in this study. We find that the Gardasil HPV vaccine caused the inflammation that resulted in virtually the same symptoms found in autistic children, confirming a direct link between failure of both methylation genes and transsulfuration gene mutations, such as CBS-699t. These numerous HPV vaccine victims confirm a direct link between vaccines and the disruption of the same or similar cognitive and motor skill functions found in autism.
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Note: the HLA-B27 Haplotype appeared to produce ANKYLOSING SPONDYLITIS in a significant number of children in our study.